Thermo Fisher, 20700, DMS (dimethyl suberimidate)

DMS (dimethyl suberimidate) Thermo Scientific Pierce DMS is dimethyl suberimidate, a membrane-permeable crosslinker that contains an amine-reactive imidoester group at each end of an 8-atom spacer arm.
Features of dimethyl suberimidate:
•Reactive groups:imidoester(both ends)
•Reactive towards:amino groups (primary amines)
• Longest of three similar imidoester crosslinkers, which include DMA, DMP and DMS
• Water-soluble
• Imidoesters react with amines at alkaline pH values (pH 8-10) to form amidine bond
• Amidine bond retains net charge character of protein primary amine to which it reacts
• Reversible at high pH values
• Tool for study of quarternary structure of proteinsProduct ReferencesCrosslinker Application Guide -- search for recent literature references for this productCell Permeability: Yes
Description: DMS
Form: Powder
Labeling Method: Chemical Labeling
Molecular Weight (g/mol): 273.
2
PEGylated: No
Product Line: Pierce™
Quantity: 1 g
Reactive Moiety: Imidoester
Shipping Condition: Ambient
Solubility: Water
Spacer Arm Length: 11.
0 Å
Water Soluble: Yes
Chemical Reactivity: Amine-Amine
Cleavable: No
Crosslinker Type: Homobifunctional
Format: Standard
Product Type: Crosslinker
Spacer: Medium (10 to 30 Å)
Unit Size: Each