Thermo Fisher, 22305, MPBH (4-(4-N-maleimidophenyl)butyric acid hydrazide)

MPBH (4-(4-N-maleimidophenyl)butyric acid hydrazide) Thermo Scientific Pierce MPBH is a long, maleimide-and-hydrazide crosslinker for conjugating sulfhydryls (cysteines) to carbonyls (aldehyde or ketones, such as those formed by oxidation of glycoprotein carbohydrates).
Features of MPBH:
•Reactive groups:maleimideandhydrazide
•Reactive towards:sulfhydryl groups and carbonyl (aldehyde) groups
• Long (17.
9A), sulfhydryl-to-aldehyde crosslinker with an aromatic ring in its spacer arm (noncleavable)
• Maleimide group reacts with sulfhydryl groups to form stable thioether linkages
• Hydrazide group conjugates to oxidized sugars of glycoproteins and carbohydrates
• Usesodium meta-periodateto oxidize glycosylation (e.
g., sialic acid) to reactive aldehyde groups
• Use withEDCto conjugate primary amine of hydrazide group to carboxyl groupsProduct References:Crosslinker Application Guide -- search for recent literature references for this productCell Permeability: Yes
Description: MPBH
Form: Powder
Labeling Method: Chemical Labeling
Molecular Weight (g/mol): 309.
75
PEGylated: No
Product Line: Pierce™
Quantity: 50 mg
Reactive Moiety: Amine, Hydrazide, Maleimide
Shipping Condition: Ambient
Solubility: DMF, DMSO
Spacer Arm Length: 17.
9 Å
Water Soluble: No
Chemical Reactivity: Carbohydrate-Sulfhydryl
Cleavable: No
Crosslinker Type: Heterobifunctional
Format: Standard
Product Type: Crosslinker
Spacer: Medium (10 to 30 Å)
Unit Size: Each