Thermo Fisher, 22363, SMPH (Succinimidyl 6-((beta-maleimidopropionamido)hexanoate))

SMPH (Succinimidyl 6-((beta-maleimidopropionamido)hexanoate)) Thermo Scientific Pierce SMPH is an amine-to-sulfhydryl crosslinker that contains NHS-ester and maleimide reactive groups at opposite ends of a long spacer arm (14.
2 angstroms).
Features of SMPH:
•Reactive groups:NHS esterandmaleimide
•Reactive towards: amino and sulfhydryl groups
• Slightly longer and more soluble thanSMPB
• NHS ester reacts with primary amines at pH 7-9, forming a stable amide bond
• Maleimide reacts with -SH groups at pH 6.
5-7.
5, forming a stable thioether bond
• Non-cleavable
• Water-insoluble (dissolve first in DMF or DMSO)Product References:Crosslinker Application Guide -- search for recent literature references for this productCell Permeability: Yes
Description: SMPH
Form: Solid
Labeling Method: Chemical Labeling
Molecular Weight (g/mol): 379.
36
PEGylated: No
Product Line: Pierce™
Quantity: 50 mg
Reactive Moiety: Maleimide, NHS Ester
Shipping Condition: Ambient
Solubility: DMF, DMSO
Spacer Arm Length: 14.
2 Å
Water Soluble: No
Chemical Reactivity: Amine-Sulfhydryl
Cleavable: No
Crosslinker Type: Heterobifunctional
Format: Standard
Product Type: Crosslinker
Spacer: Medium (10 to 30 Å)
Unit Size: Each