Thermo Fisher, 26101, Pierce™ Traut's Reagent (2-iminothiolane)

Pierce™ Traut's Reagent (2-iminothiolane) Thermo Scientific Pierce Traut's Reagent (2-iminothiolane) is a small thiolation compound that reacts with primary amines (e.
g., lysine side chains) to add a small spacer arm (8.
1 angstroms) terminated by a free sulfhydryl group.
Features of Thermo Scientific Pierce Traut's Reagent (2-iminothiolane):
•Simple—one-step conversion of amines to sulfhydryls
•Specific—selective and spontaneous modification of primary amines at pH 7-10
• Preserves positive charge to maintain protein solubilityTraut's Reagent (2-iminothiolane or 2-IT) is a cyclic thioimidate compound for thiolation (sulfhydryl addition). Traut's Reagent reacts with primary amines (—NH2) to introduce sulfhydryl (—SH) groups while maintaining charge properties similar to the original amino group. Once added, sulfhydryl groups can be specifically targeted for reaction in a variety of useful labeling, crosslinking and immobilization procedures.
Flexible—incorporates a five-atom spacer arm to reduce steric hindrance
•Soluble—preserves the original positive charge to preserve protein solubilityForm: Powder
Label Type: Conjugating Groups
Label or Dye: Sulfhydryl Group
Product Line: Pierce™
Quantity: 500 mg
Solubility: DMF, DMSO
Chemical Reactivity: Amine
Product Type: Thiophilic Adsorption Kit
Spacer: Short (<10 Å)
Unit Size: Each