Thermo Fisher, 28100, PMPI (p-maleimidophenyl isocyanate)

PMPI (p-maleimidophenyl isocyanate) Thermo Scientific Pierce PMPI is a maleimide-and-isocyanate crosslinker for attaching compounds to sulfhydryl groups (cysteines) after conjugating the linker to hydroxyl groups on a molecule by urethane (carbamate) bonds.
Features of PMPI:
•Reactive groups:maleimideandisocyanate
•Reactive towards:sulfhydryl and hydroxyl groups
• Short (8.
7A), sulfhydryl-to-hydroxyl crosslinker with an aromatic spacer arm (noncleavable)
• Maleimide group reacts with sulfhydryl groups to form stable thioether linkages
• Isocyanate reacts with non-aqueous hydroxyl groups to form carbamate linkage
• Excellent tool for conjugating hydroxyl-containing compounds such as steroids and vitamins
• Targets and reaction solutions must not contain primary aminesCell Permeability: Not determined
Description: PMPI
Form: Solid
Labeling Method: Chemical Labeling
Molecular Weight (g/mol): 307.
1
PEGylated: No
Product Line: Pierce™
Quantity: 50 mg
Reactive Moiety: Maleimide, Isocyanate
Shipping Condition: Ambient
Solubility: DMF, DMSO
Spacer Arm Length: 8.
7 Å
Water Soluble: No
Chemical Reactivity: Carboxyl-Sulfhydryl
Cleavable: No
Crosslinker Type: Heterobifunctional
Format: Standard
Product Type: Crosslinker
Spacer: Short (<10 Å)
Unit Size: Each