Thermo Fisher, A30085, Silencer™ Select Human Epigenetics siRNA Library

Silencer™ Select Human Epigenetics siRNA Library Epigenetic regulation of gene expression is proving to be key in the development and progression of a host of human diseases. TheSilencer™ Select Human Epigenetics siRNA Library contains 1563 Ambion™SilencerSelect highly potent, chemically-modified siRNAs targeting 521 epigenetic enzymes, including those mediating epigenetic signaling through the acetylation and methylation of histones. This library was designed using the most up-to-date genome databases, including the NCBI RefSeq database and cross-referenced to the Gene Ontology Consortium (GO) database and/or the HUGO Gene Nomenclature Committee (HGNC). TheSilencerSelect siRNAs are designed using Thermo Fisher Scientific's leading design algorithms—along with our novel locked nucleic acid (LNA) modifications, this helps to ensure the efficacy, specificity and potency required for accurate and consistent phenotype data for RNAi screening against epigenetic gene knockdown studies.
Superior efficacy—Reduce off target effects by up to 90% due to latest design algorithms and LNA chemical modificationsHighest efficiency—Perform knockdown studies with 100-fold more potent siRNAs than currently available siRNAsDependable—Achieve faster discoveries via consistency of gene knockdown and reliability of phenotypic resultsConvenient—Reduce data de-convolution and accelerate target validation with our arrayed formatCustomizable—Choose the best option for your workflow demands, including additional siRNA scales and pooled formatsWhy use theSilencerSelect Human Epigenetics siRNA Library?Together with careful bioinformatics selection of gene targets,SilencerSelect siRNAs are optimized using our most up-to-date design algorithms, proprietary chemical modifications and high quality synthesis to help ensure desired RNAi outcomes. TheSilencerSelect Human Epigenetics siRNA Library contains our pre-designed and when available, validated siRNAs generated with highest potency and specificity in mind so you can focus on the highest data quality instead of performance issues. Thermo Fisher Scientific's AmbionSilencerSelect siRNAs are also backed by the best in industry guarantee.
SilencerSelect siRNA libraries empower you with highly potent siRNAs to maximize discovery with even lessAmbionSilencerSelect siRNAs are designed with the highest potency of available siRNAs, resulting in 100-fold more potent siRNAs and allowing gene knockdowns at the lowest concentrations (see figure below). The highly potentSilencerSelect siRNAs allow you to use even lower concentrations of siRNAs, which helps to minimize off target effects, reduce false negative data and maximize siRNA library output for additional screens and data validation. TheSilencerSelect Human Epigenetics siRNA Library contains 0.
25 nmol of each highly potent siRNA, sufficient for at least 500 transfections (at 5 nM siRNA, 100 μL transfection volume).
Flexibility to meet your workflow needsThermo Fisher Scientific offers a comprehensive list of pre-defined or custom siRNA libraries against human, mouse or rat genes with 1, 2, or 5 nmol of each siRNA or larger sizes. For a complete gene list, additional information or to discuss your research with one of our technical experts, contact your local sales representative or e-mail us at RNAilibraries@lifetech.
com.
For Use With (Application): RNAi
Product Line: Silencer™Select
Product Type: siRNA Library
Purity: Standard
Quantity: 1 Set
Shipping Condition: Approved for shipment at Room Temperature or on Wet Ice
Format: 96-well Plate
RNAi Type: siRNA
Species: Human
Unit Size: Each