Waters, 186009281, IonHance CX-MS pH Concentrate B pH 8.5 in MS Certified LDPE Container (10X Concentrate)

Designed alongside the BioResolve SCX columns, the IonHance CX-MS pH 10X Concentrate B,  in MS Certified LDPE Container, was carefully optimized for use in creating a gradient for LC/MS analysis of mAb charge variant separations.

Specifications
Separation Mode: Ion Exchange Chromatography
Detection Method: LCMS
Formulation: Liquid
Storage Condition: Room Temperature
System Type: LC/MS
Shelf Life: 12 Months
Shelf life upon reconstitution: 1 Week
Volume: 100 mL
Type: Mobile Phase
UNSPSC: 41116107
Application: Protein
Brand: IonHance
Product Type: Standards
Units per Package: 1 pk

Additional Information
IonHance CX-MS pH Concentrate B pH 8.5 in MS Certified LDPE Container (10X Concentrate) Cation-exchange chromatography linked to mass spectrometry (CX-MS) analysis of native proteins is a reliable method of identifying micro heterogeneities in biopharmaceuticals, notably monoclonal antibodies (mAbs). Charge-variant analysis can be used with CX-MS to fingerprint chemical and enzymatic alterations that occur throughout the manufacture, purification, formulation, and storage of mAbs. These changes have the potential to impact the structure and biological action of medicines; thus they must be identified. Due to the use of nonvolatile salts and high ionic strength, ion-exchange chromatography (IEX) was formerly incompatible with mass spectrometry. The introduction and improvement of volatile, salt-mediated pH gradients, on the other hand, allows CX-MS to be used. Waters has built a solid CX-MS platform that includes BioResolveTM SCX mAb 3 μm Columns, trace metal certified labware, and tailored buffers. These lab equipment are useful for both intact and subunit mAb studies. High mass spectrum quality is ensured by WatersTM IonHanceTM CX-MS pH Concentrate B. The lab equipment comes in one-liter trace metal certified low-density polyethylene bottles with 100 mL aliquots of 10x strength combinations (proven trace ppb values of sodium, potassium, and calcium). Concentrate B is designed to produce a 160 mM ammonium acetate mobile phase with a pH of 8.5. In addition to this, these concentrates are made with 20% acetonitrile to prevent bacterial development. We recommend that you also explore and invest in the BioResolve SCX mAb Column with VanGuard FIT, 3 µm, 2.1 mm X 50 mm, 1/pk. BioResolve SCX mAb columns are 3 μm corrosion-resistant columns that comprise non-porous polymer-based particles grafted with a multi-component network of negatively charged sulfonic acid ligands that has been thoroughly tuned. Using robust salt or pH gradient approaches, this unique column technology enables consistent, high-resolution, charged-based separations of mAbs and other proteins in both LC and LC-MS applications. This package also incorporates VanGuardTM Fully Integrated Technology (FIT), which extends the life of the column without compromising biomolecule component resolution.

FAQ
What Is The Shelf Life Of The IonHance CX-MS pH Concentrate B pH 8.5 in MS Certified LDPE Container (10X Concentrate)? The IonHance CX-MS pH Concentrate B pH 8.5 in MS Certified LDPE Container (10X Concentrate) listed here has a shelf life of 12 Months. What Is The Shelf Life Of The IonHance CX-MS pH Concentrate B pH 8.5 in MS Certified LDPE Container (10X Concentrate) Upon Reconstitution? Upon Reconstitution, the product’s shelf life is 1 Week.